Approved proposals

List of approved research proposals for the liver trial (WP2)

Reference

Title

Lead Author & Main contact

Organisation

Core research

Status

Liver-01-OX-141015

Defining the molecular signature of perfusate quality during normothermic machine preservation.

University of Oxford

Yes

Analysis complete, results in process.

Liver-02-OX-141015

Evaluating ischemia reperfusion injury in livers following normothermic preservation, defining the effect on serum profiles of recipients.

University of Oxford

Yes

Analysis complete, results in process.

Liver-03-OX-141015

Defining the molecular signature of liver quality during preservation and the influence of normothermic machine preservation

University of Oxford

Yes

Analysis complete, results in process.

Liver-04-OX-140819

Mechanisms Underlying the Efficacy of NMP in Human Liver Transplantation

University of Oxford

No

Completed

Liver-05-OX-141006

Effect of preservation modality on ischaemia-reperfusion injury

King's College London

Yes

Analysis underway

Liver-06-OX-141006

Metabolic effects of normothermic machine perfusion in human liver transplantation

University of Oxford

Yes

Completed

Liver-09-GESTP-141104

Does normothermic machine perfusion decrease activation of hepatic stellate cells during organ preservation?

University Clinic Essen

No

Not yet started

Liver-10-OX-141119

Bile Production During Normothermic Liver Perfusion

David Nasralla

University of Oxford

No

Completed

Liver-11-BLETP-150522

Production of VWF and FVIII by perfused liver as a function of time

University Hospital Leuven

No

Complete

Liver-12-OX-150714

Mechanisms Underlying the Efficacy of NMP in Human Liver Transplantation

University of Oxford

No

Complete

Liver-13-OX-151104

The effects of normothermic machine perfusion on human steatotic livers utilised for transplantation

University of Oxford

No

Complete

Liver-15-QEH-141103

Correlation of Acute Kidney Injury Post OLT with Ischaemia/Reperfusion in the Graft

Queen Elizabeth Hospital Birmingham

No

Complete

Liver-16-QEH-141028

Comparing  cardiovascular stability during liver transplants using normothermic perfusion and conventional cold storage

HJ Cilliers

Queen Elizabeth Hospital Birmingham

No

Not yet started

Liver-17-QEH-141107

Early Thrombosis and Fibrinolysis in Normothermic Machine Perfused Livers

Garrett Roll

Queen Elizabeth Hospital Birmingham

No

Not yet started

Liver-19-QEH-141105

Assessment of ischaemic  necrosis in donor livers and changes which occur during machine perfusion and post-transplantation

Queen Elizabeth Hospital Birmingham

No

Not yet started

Liver-20-QEH-141105

Role of insulin receptors in initial function of the liver allograft

Queen Elizabeth Hospital Birmingham

No

Not yet started

Liver-21-QEH-140813

The use of Kynurenine as a potential biomarker to predict the liver graft function

Thamara Perera

Queen Elizabeth Hospital Birmingham

No

Not yet started

Liver-22-KCL-160526

Assessment of the quality of DCD grafts after normothermic machine perfusion (NMP)

King's College London

No

Not yet started

Liver-23-KCL-160531

Using lipidomics to predict liver quality

King's College London

No

Not yet started

Liver-24-KCL-160526

Defining the role of NK cells in liver grafts prior and post normothermic machine perfusion (NMP)

King's College London

No

Not yet started

Liver-25-collaboration-161024

Collaborative Research group on Bile Duct research in the NMP trial

University Leuven, Queen Elizabeth Birmingham, Addenbrooke's Cambridge, University Oxford

No

Analysis underway

Liver-26-HCB-170406

Evaluation of the feasibility of ex-vivo normothermic machine perfusion when retrieving liver graft from Type II DCD donors

Hospital Clinic Barcelona

No

Approved by the Trial Monitoring Committee and the Management Board on 22 May 2017

List of approved research proposals for the POMP trial (WP3)

Reference

Title

Lead Author & Main contact

Organisation

Core research

Status

POMP-01-OX-141015

Does hypothermic reconditioning by machine perfusion with oxygen preserve mitochondrial function and restore ATP level, improving kidney transplantation outcome?

University of Oxford

Yes

Recruitment complete, trial results under analysis.

POMP-02-OX-141015

Does hypothermic reconditioning by machine perfusion with oxygen reduce IRI, prevent cell death and improve graft survival?

University of Oxford

Yes

Recruitment complete, trial results under analysis.

POMP-03-OX-141015

Does oxygenated HMP preserve mitochondrial bioenergetics?

University of Oxford

Yes

Recruitment complete, trial results under analysis.

POMP-04-OX-141015

Does oxygenated HMP reduce IRI in the kidneys by induction of cytoprotective enzyme expression?

University of Oxford

Yes

Recruitment complete, trial results under analysis.

POMP-05-BLETP-140325

Predictive accuracy of perfusion parameters for kidney graft outcome in the WP3 trial.

University Hospital Leuven

Yes

Recruitment complete, trial results under analysis.

POMP-06-BLETP-140325

The autophagy-apoptosis-necrosis balance in cold storage versus end ischemic oxygenated hypothermic machine perfusion kidney grafts

Jean-Paul Decuypere

University Hospital Leuven

No

Recruitment complete, trial results under analysis.

POMP-07-GBOTP-141022

Epigenetic modifications by ischemic kidney preservation w or w/o subsequent oxygenated HMP: Does oxygenation modulate genetic proclivity towards tissue fibrosisIs and regeneration?

University Clinic Essen

No

Recruitment complete, trial results under analysis.

POMP-08-GSTEP-170914

Alarmin release as predictor for immunogenicity of the renal allograft

Benjamin Wilde

University Clinic Essen

No

Recruitment complete, trial results under analysis.

List of approved research proposals for the COMPARE trial (WP4)

Reference

Title

Lead Author & Main contact

Organisation

Core research

Status

COMPARE-01-OX-141009

Comparison of proteomics and metabolomics signatures in perfusate of DCD kidneys during HMP +/- O2

University of Oxford

Yes

Sample selection pending

COMPARE-02-OX-141009

Transcriptomics and proteomics signatures of kidney regeneration following O2 HMP -

Is the quality of kidneys obtained from older DCDs improved after oxygenated HMP?

University of Oxford

Yes

Sample selection pending

COMPARE-03-OX-141009

Identification of miRNAs  in the oxygenated when compared to non- oxygenated tissue biopsies and perfusates as potential targets of regeneration.

University of Oxford

Yes

Sample selection pending

COMPARE-04-BLETP-140325

Predictive accuracy of perfusion parameters for kidney graft outcome in the COMPARE trial

University Hospital Leuven

Yes

Sample selection pending

COMPARE-05-BLETP-140325

Serum injury markers and prediction of kidney transplant outcome

University Hospital Leuven

Yes

Sample selection pending

COMPARE-06-BLETP-140606

The autophagy-apoptosis-necrosis balance in kidney grafts after hypothermic machine perfusion with or without oxygen

Jean-Paul Decuypere

University Hospital Leuven

No

Sample selection pending

COMPARE-07-BLETP-141215

The effect oxygenated kidney preservation on DNA methylation in kidney transplantation

University Hospital Leuven

No

Sample selection pending

COMPARE-08-BLETP-170530

Prevention of ischaemia-induced DNA hypermethylation by oxygenation during kidney transplant preservation.

University Hospital Leuven

No

Sample selection pending

COMPARE-09-BLETP-180719

Is preservation time a risk factor for DGF / one year graft function / one year graft survival in DCD 50+ kidneys preserved by HMP+O2?

Ina Jochmans

University Hospital Leuven

No

Sample selection pending

If you would like to contribute to an existing research proposal, please contact the Lead Author by clicking on the name listed or get in touch with the project office through cope@nds.ox.ac.uk

This project has received funding from the European Union's 7th Framework Programme for research, technological development and demonstration under grant agreement 305934.

COPE Consortium - 2018